Cancer care is in the midst of a revolution in digital health innovations, payment reform, and attention to the downstream physical, psychosocial, and financial consequences of therapies. Unfortunately, much of this revolution has not yet touched marginalized populations. We apply rigorous methods to evaluate the impact of cancer-related policies, develop methods to identify downstream consequences of cancer therapy, and uncover disparities in cancer treatment. Our vision is to expose problems and evaluate solutions to create a better cancer care system in the US.